Significance of lysogeny for the Metabolism of Desulfovibrio spp. Strains Isolated From Aquatic Environments of Georgia

EPTC

Abstract Aims: Sulphate-reducing bacteria (SRB) are ecologically important group of anaerobic micro-organisms that can reduce sulphate to form hydrogen sulphide-a toxic gas causing iron corrosion on metal surfaces. In this work, SRB strains were isolated from aquatic environments in the country of Georgia to determine their lysogenicity and the role of temperate phages in host metabolism.…

Phage Therapy Experience at the Eliava Phage Therapy Center: Three Cases of Bacterial Persistence

EPTC

Abstract In this retrospective descriptive study we focus on cases of three patients who underwent phage therapy procedures at Eliava Phage Therapy Center (EPTC) in Tbilisi, Georgia. Patients with chronic infectious diseases related to Pseudomonas aeruginosa (two patients, lower respiratory tract infection (LRTI)) and Klebsiella pneumoniae (one patient, urinary tract infection (UTI)) are among those very few EPTC patients…

Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets

EPTC

Abstract Bacteriophages that lyse Salmonella enterica are potential tools to target and control Salmonella infections. Investigating the host range of Salmonella phages is a key to understand their impact on bacterial ecology, coevolution and inform their use in intervention strategies. Virus–host infection networks have been used to characterize the “predator–prey” interactions between phages and bacteria…

Case Report: Chronic Bacterial Prostatitis Treated With Phage Therapy After Multiple Failed Antibiotic Treatments

EPTC

Background: Chronic Bacterial Prostatitis (CBP) is an inflammatory condition caused by a persistent bacterial infection of the prostate gland and its surrounding areas in the male pelvic region. It is most common in men under 50 years of age. It is a long-lasting and debilitating condition that severely deteriorates the patient’s quality of life. Anatomical limitations and…

Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma

EPTC

The airway epithelium is the primary site where inhaled and resident microbiota interacts between themselves and the host, potentially playing an important role on allergic asthma development and pathophysiology. With the advent of culture independent molecular techniques and high throughput technologies, the complex composition and diversity of bacterial communities of the airways has been well-documented…

Bacteriophage Therapy as a Potential Management Option for Surgical Wound Infections

EPTC

Abstract To investigate the potential role of bacteriophages in the treatment of surgical infections, we conducted a retrospective analysis of four surgical patients who have sought treatment at the Eliava Phage Therapy Center, Tbilisi, Georgia. Two patients had chronic osteomyelitis, one presented with a diabetic foot ulcer, and the fourth patient had developed a severe…

Bacteriophages

EPTC

Introduction Even bacteria can get a virus! The viruses that infect bacteria are called bacteriophages, and certain bacteriophages have been studied in detail in the lab (making them some of the viruses we understand best).In this articles, we’ll take a look at two different cycles that bacteriophages may use to infect their bacterial hosts: The lytic cycle:…

Phage to Rescue

EPTC

Bacteriophages are used to infect and kill pathogenic multidrug-resistant bacteria. ARCHANA JYOTI brings you a report on how the therapy has become talk of the town Like many hospitals across the world, Vellore-based Christian Medical College (CMC) too is grappling with infectious bacteria (Supebugs) that resists anti-biotics. The doctors at the CMC hospitals have decided to try…